nr0b2b nuclear receptor subfamily 0, group B, member 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr0b2bprovided by ZNC
Official Full Name: nuclear receptor subfamily 0, group B, member 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080403-9
See related: Ensembl:ENSDARG00000102756 AllianceGenome:ZFIN:ZDB-GENE-080403-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gb:dq017630
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in circadian rhythm; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (14153366..14155999, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (14291182..14293804, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0, group B, member 2b

Names: NR0B2-B; SHP-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386343.1 → NP_001373272.1 nuclear receptor subfamily 0, group B, member 2b

Status: VALIDATED

Source sequence(s)

CU905504

UniProtKB/TrEMBL

A0A8M1Q7C6

Conserved Domains (1) summary

cl11397
Location:27 → 241

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

14153366..14155999 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001338242.5 → XP_001338278.1 nuclear receptor subfamily 0 group B member 2

Related

ENSDARP00000133307.1, ENSDART00000169232.2

Conserved Domains (1) summary

cl11397
Location:27 → 241

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators